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06-21-2024, 01:53 PM | #31 | |||
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Grand Magnate
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Preliminary Surface View
TruGrit: DiPALS & RespiStimALS - Google Drive This chart abstracts the losses during the DiPALS and RespiStimALS clinical trials. The losing cohort in each temporal period is denoted in red; note the DiPALS control cohort is the only cohort with two losses; the DiPALS treatment cohort lost only once, . . . both of RespiStimALS cohorts are surgical cohorts but they incurred no loss temporal periods. In fact the RespiStimALS early stim cohort clearly outperformed the DiPALS NiV cohort (56 to 49 moons) and the sham RespiStimALS cohort might have if their effort was not curtailed by the possible problem DiPALS encountered. |
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06-25-2024, 09:32 AM | #32 | |||
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Grand Magnate
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Quote:
pacing patients in |
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06-28-2024, 02:54 PM | #33 | |||
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Grand Magnate
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Interventional procedure overview of intramuscular diaphragm stimulation for ventilator-dependent chronic respiratory failure caused by motor neurone disease
https://www.nice.org.uk/guidance/ipg...ments/overview UK NICE = National Institute for health and Care Excellence Note the expression on the cover page: " . . .It should not be regarded as a definitive assessment of the procedure . . . " 🍦🍦🍦🍨🍦🍦🍦 |
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07-11-2024, 11:21 AM | #34 | |||
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Grand Magnate
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One would EXPECT weaker results when fewer patients of a clinical trial cohort undergo an efficacious intervention, especially when those who did not undergo the intervention are included in the tabulations. Such weaker results would tend to corroborate rather than refute the efficacy claim, however stronger results may not. DiPALS did not accumulate sufficient information to form an independent opinion on the merits of the intervention's value and thus can not responsibly argue the intervention has general value because they do not have enough data for making the case. They wanted to consider the possibility certain subgroups might benefit from the intervention but could only advocate future research strive for improving the differentiation of candidate cases.
An important issue here is saving a distressed clinical study when the syndrome under consideration is highly variant in its effect on patients and getting partial value out of the developed results. |
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07-12-2024, 10:34 AM | #35 | |||
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Grand Magnate
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Steve Gleason delivers powerful speech as former NFL star is honored at 2024 ESPY Awards
2024 ESPY Awards: Steve Gleason delivers powerful speech as former NFL star is honored | CNN |
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08-14-2024, 02:41 PM | #36 | |||
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Grand Magnate
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Found a reference in the Getty Images database, which caption dated 18 October 2023 read this patient continues alive in Northbridge, MA . . . the image itself is not available . . . or maybe costs hundreds . . .
Discovered today: First patient implanted in Massachusetts Device helps ALS patient beat the odds – Boston Herald and Israeli 'AK' data on the web shows both have crossed their twenty year mark! Congratulations. |
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08-26-2024, 12:07 PM | #37 | |||
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Grand Magnate
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The Role of Biomarkers in ALS
The Role of Biomarkers in ALS | NEALS Long the bane of medical research in Amyotrophic Lateral Sclerosis is the absence of biomarkers, which is the main topic of the afore referenced webinar. Another value of β-phragm pacing is the possibility of high precision though temporally limited biomarkers, referenced in this journal paper: Identification of unexpected respiratory abnormalities in patients with amyotrophic lateral sclerosis through electromyographic analysis using intramuscular electrodes implanted for therapeutic diaphragmatic pacing Identification of unexpected respiratory abnormalities in patients with amyotrophic lateral sclerosis through electromyographic analysis using intramuscular electrodes implanted for therapeutic diaphragmatic pacing - PubMed |
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08-28-2024, 01:07 PM | #38 | |||
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Grand Magnate
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Unofficial status of study WEB Pacer cohorts: SCALED
Unofficial status of study WEB Pacer cohorts: SCALED - Google Drive There are 185 who underwent the intervention (implantation), there are 246 whose status regarding implant is unknown and they are presumed negative for implant. For comparison one could scale the 185 up (133%) or 246 down (75%), so columns for both are included. The pacer wins up to ten years; at this time is tied at ten years, behind by about one or two at the Texas threshold and by about three at the twenty year threshold. There are three bracketed thresholds, which have no historical backgrounds (but at present, with very low N, there is one tie and two losses). At least four patients were ineligible for implant because they were already long term survivors when the intervention became available. Hence it could be said, under scaled analysis the pacer wins all the categories . . . however, several continue to make headway and more improvement appears likely. |
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